Evaluation of the role of CD47 in sickle cell disease

Abstract CD47 is a self-marker expressed on the surface of RBCs and work to prevent process phagocytosis. SIRPα ligand that phagocytic cells, such as macrophages, control removal dead/diseased cells. This study aimed examine expression PBMC cells in SCD patients apoptosis RBCs. We also measured levels pro-inflammatory cytokines correlated it with cell marker determine whether and/or played role promoting phenotype SCD. Whole blood samples were drawn from patients, healthy isolated stained SIRPα. Change CD47, by annexin V marker, correlation among these variants was determined. The significantly decreased increased patients. A higher level cytokines, IL-6 IL-1β, found IL-1β be inversely expression. Our data showed erythrocytes reduced those Based we suggest would impacted CD47. An inverse relationship between production